Dermasol Cream 20g Clobetasol Propionate
> COMPOSITION Dermasol® 0.05% cream: Each 20 gm cream contains Clobetasol Propionate BP 5 mg. PHARMACOLOGY Clobetasol Propionate is a highly potent topical steroid. It has both local anti inflammatory and immunosuppressive activity. Clobetasol, as the Propionate salt, is only used topically on the skin and its effects are limited to the local anti inflammatory activity. When given systemically it has standard glucocorticoid activity and binds with high affinity to the glucocorticoid receptor. Clobetasol Propionate inhibits the adherence of neutrophils and monocyte-macrophages; to the capillary endothelial cells of inflammed area. Clobetasol blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. INDICATION is indicated in: 1. Initial control of all forms of hyperacute eczema in all age groups 2. Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex 3. Chronic hyperkeratotic psoriasis of